Glycoprotein that helps the body fight viruses

Granoff DM. Relative importance of complement-mediated bactericidal and opsonic activity for protection against meningococcal disease. Interaction of the Legionnaires' disease bacterium Legionella pneumophila with human phagocytes.

Antibodies in action: role of human opsonins in killing Salmonella enterica serovar Typhi. Eur J Immunol. Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis.

Zaragoza O, Casadevall A. Monoclonal antibodies can affect complement deposition on the capsule of the pathogenic fungus Cryptococcus neoformans by both classical pathway activation and steric hindrance. Cell Microbiol.

Zhong Z, Pirofski LA. Antifungal activity of a human antiglucuronoxylomannan antibody. Clin Diagn Lab Immunol. Taborda CP, Casadevall A. Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait. Protection by alpha-thalassaemia against Plasmodium falciparum malaria: modified surface antigen expression rather than impaired growth or cytoadherence.

Immunol Lett. Increased susceptibility of malaria-infected variant erythrocytes to the mononuclear phagocyte system. Blood Cells. Early phagocytosis of glucosephosphate dehydrogenase G6PD -deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. The role of complement, antibody, and tumor necrosis factor alpha in the killing of Plasmodium falciparum by the monocytic cell line THP Role of immune serum and complement in stimulation of the metabolic burst of human neutrophils by Plasmodium falciparum.

Pang XL, Horii T. Complement-mediated killing of Plasmodium falciparum erythrocytic schizont with antibodies to the recombinant serine repeat antigen SERA Vaccine. Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs Transmission-blocking antibodies against multiple, non-variant target epitopes of the Plasmodium falciparum gamete surface antigen Pfs are all complement-fixing.

Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum. Transmission blockade of Plasmodium falciparum malaria by anti-Pfsspecific antibodies is isotype dependent. Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. Mechanisms in immune animals. Microbes Infect. Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia.

Mol Med. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. Protection against murine cytomegalovirus infection by passive transfer of neutralizing and non-neutralizing monoclonal antibodies.

Horton RE, Vidarsson G. Antibodies and their receptors: different potential roles in mucosal defense. Front Immunol. Takai T. Roles of Fc receptors in autoimmunity. Nat Rev Immunol. Molecular basis for a polymorphism involving Fc receptor II on human monocytes. A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.

Ravetch JV, Perussia B. Cell type-specific expression of two genes that differ in single nucleotide substitutions. Characterization of polymorphic forms of Fc receptor III on human neutrophils.

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Differences between the activities of human monoclonal IgG1 and IgG3 anti-D antibodies of the Rh blood group system in their abilities to mediate effector functions of monocytes.

Fc-glycosylation influences Fcgamma receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G Lux A, Nimmerjahn F. Impact of differential glycosylation on IgG activity. Forthal DN, Moog C. Fc receptor-mediated antiviral antibodies. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. Antibody from patients with acute human immunodeficiency virus HIV infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cells.

A serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody requires Fcgamma receptor III and macrophages to mediate protection against pneumococcal pneumonia in mice. Anti-peptidoglycan antibodies and Fcgamma receptors are the key mediators of inflammation in Gram-positive sepsis. J Leukoc Biol. Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria.

Interactions between natural killer cells and antibody Fc result in enhanced antibody neutralization of human immunodeficiency virus type 1. Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells.

Biochem Soc Trans. Nonclinical studies addressing the mechanism of action of trastuzumab Herceptin Semin Oncol. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.

Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus. Glycoprotein G of herpes simplex virus 2 as a novel vaccine antigen for immunity to genital and neurological disease. Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms. J Reprod Immunol. Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity.

New paradigms for functional HIV-specific nonneutralizing antibodies. K lymphocytes and monocytes are effective against meningococi in cooperation with human imune sera.

Antibody-dependent cell-mediated antibacterial activity: K lymphocytes, monocytes, and granulocytes are effective against shigella. Antibody-dependent cell-mediated antibacterial activity of intestinal lymphocytes with secretory IgA. IgA-dependent cell-mediated activity against enteropathogenic bacteria: distribution, specificity, and characterization of the effector cells.

IgA-driven antibacterial activity against Streptococcus pneumoniae by mouse lung lymphocytes. Am Rev Respir Dis. Messick JB, Rikihisa Y. Presence of parasite antigen on the surface of PD1 cells infected with Ehrlichia risticii.

Antibody-dependent cellular cytotoxicity of Coxiella burnetii-infected J macrophage target cells. Cytotoxic antibody dependent cells in mice experimentally infected with Brucella abortus. Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent.

BMC Immunol. Kazura JW. Host defense mechanisms against nematode parasites: destruction of newborn Trichinella spiralis larvae by human antibodies and granulocytes. Immune killing of newborn Trichinella larvae by human leucocytes. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Capron M, Capron A.

Immunoglobulin E and effector cells in schistosomiasis. Protective immunity induced by the full-length cDNA encoding paramyosin of Chinese Schistosoma japonicum.

Capron A. Schistosomiasis: forty years' war on the worm. Parasitol Today. A new function for platelets: IgE-dependent killing of schistosomes. Immunity in human schistosomiasis mansoni. Regulation of protective immune mechanisms by IgM blocking antibodies. Antibody response of Schistosoma mansoni-infected human subjects to the recombinant P28 glutathione-S-transferase and to synthetic peptides.

Lawrence RA. Immunity to filarial nematodes. Vet Parasitol. IgE antibody-mediated cytotoxicity of rat macrophages against microfilaria of Dipetalonema citeae in vitro. Clin Exp Immunol. Weiss N, Tanner M. Studies on Dipetalonema viteae Filarioidea 3.

Antibody-dependent cell-mediated destruction of microfilariae in vivo. Tropenmed Parasitol. Antibody-dependent cell-mediated effects in bancroftian filariasis. Immune responses in human Brugia malayi infections: serum dependent cell-mediated destruction of infective larvae in vitro. Characterization of a monoclonal antibody against infective larvae of Brugia malayi. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Antibody-facilitated macrophage killing of Trypanosoma musculi is an extracellular process as studied in several variations of an in vitro analytical system.

Townsend J, Duffus WP. Trypanosoma theileri: antibody-dependent killing by purified populations of bovine leucocytes. Kierszenbaum F, Hayes MM. Mechanisms of resistance against experimental Trypanosoma cruzi infection. Requirements for cellular destruction of circulating forms of T.

Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates. Immunity to a challenge infection of Strongyloides stercoralis third-stage larvae in the jird. In vitro interactions between murine neutrophils and Eimeria falciformis sporozoites. Res Immunol. Human host response to Giardia lamblia.

Antibody-dependent killing in vitro. Cell Immunol. Khusmith S, Druilhe P. Cooperation between antibodies and monocytes that inhibit in vitro proliferation of Plasmodium falciparum. Forthal DN, Landucci G. In vitro reduction of virus infectivity by antibody-dependent cell-mediated immunity. J Immunol Methods. Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells. Blood clearance of Plabeled vesicular stomatitis and Newcastle disease viruses by the reticuloendothelial system in mice.

Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma. Ontogeny of the immune response. The role of antigen elimination in the true primary immune response in germfree, colostrum-deprived piglets. Duration of Passive Immunity. J Hyg Lond ; 22 — Fujisawa H. Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice.

Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.

Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice. Neutrophils do not bind to or phagocytize human immune complexes formed with influenza virus. Human monocytes are unable to bind to or phagocytize IgA and IgG immune complexes formed with influenza virus in vitro.

FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. Immunol Cell Biol.

The role of Fcgamma receptor polymorphisms and C3 in the immune defence against Neisseria meningitidis in complement-deficient individuals. Fc gamma receptor IIa CD32 polymorphism in fulminant meningococcal septic shock in children.

The Ebola virus can jump from bats to other species such as humans and apes Figure 1. Ebola virus infections occur when viral particles are absorbed through the mouth, the skin, or through skin wounds. Humans can become infected when handling sick or dead infected animals or by close contact with bats that have the virus.

They can also be infected by other humans, for example by contact with blood, saliva, urine, breast milk, semen, sweat, stool, or vomit from infected people.

Humans can also be infected through soiled clothing, bedding, gloves, protective equipment, and medical waste, such as syringes.

You can see why people need to use extreme caution if they deal with infected patients in hospitals or dead people at funerals. Ebola virus has been extensively studied by scientists. Ebola virus is a member of a family of viruses called Filoviridae. Filovirus are filamentous viruses, so named because there are fin and elongated.

The RNA genome and various proteins that help the virus to replicate itself are enclosed within a protective layer called the viral envelope. The envelope has protruding molecules on its surface called spike glycoproteins. The spike glycoproteins help the virus to penetrate and infect cells Figure 2. If an infection occurs, the immune system of an infected animal will spot these spike glycoproteins and will fight the virus, by calling its immune soldiers onto the field.

Ebola virus disease does not start right away after infection. There is a lag of 2—21 days, called the incubation period, before the replication of the virus causes the first symptoms appear.

Ebola virus disease starts with high fever, malaise, fatigue, and body aches. Then gastrointestinal symptoms, such as vomiting and diarrhea, appear, which lead to drastic fluid losses of up to 10 l a day.

While some patients recover, others suffer from bleeding and kidney damage, eventually leading to multiple organ failure and death. To diagnose Ebola virus disease, a blood sample is taken from the infected person and examined for the presence of viral particles. Against microbes, and viruses in particular, there are two modes of protection. This phase also helps researchers understand how well a vaccine works over a longer time frame and how safe it is for the population.

This article was published on. What our experts say Some vaccines, including the Oxford Astra-Zeneca vaccine, are developed using something called a viral vector. Context and background There have been several information pieces online falsely claiming that the vaccine injects DNA sequences of various diseases that then make vaccinated individuals succumb to those diseases.

Can they overcome their checkered past? Media briefing. Media Release Published by. Expert Comments: No items found. Health Desk Newsletter Health information in your inbox, every other week Success! An email has been sent to you to confirm your subscription. Health Desk, Expression and evaluation of Chikungunya virus E1 and E2 envelope proteins for serodiagnosis of Chikungunya virus infection. Yonsei Med J. Chikungunya virus infection: an overview.

New Microbiol. Detection of antibodies to human immunodeficiency virus HIV that recognize conformational epitopes of glycoproteins and 41 often allows for early diagnosis of HIV infection. Chikungunya Virus, Centers for disease control and prevention.

Chirmule N, Pahwa S. Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions. Microbiol Rev. Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly. Purification of the influenza hemagglutinin glycoprotein and characterization of its carbohydrate components.

J Virol. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor.

Das R. Dawson GJ. Assembly of the coronavirus envelope: homotypic Interactions between the M proteins. Geneva: World Health Organization; Shedding of Ebola virus surface glycoprotein is a mechanism of self-regulation of cellular cytotoxicity and has a direct effect on virus infectivity.

Biosynthesis and role of filoviral glycoproteins. J Gen Virol. Fenouillet E, Jones IM. The glycosylation of human immunodeficiency virus type 1 transmembrane glycoprotein gp41 is important for the efficient intracellular transport of the envelope precursor gp Dengue virus type 1 nonstructural glycoprotein ns1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion.

Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Macbinding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma.

J Gastroenterol. Influenza hemagglutinin and neuraminidase membrane glycoproteins. J Biol Chem. Development and characterization of mouse monoclonal antibodies against monomeric dengue virus non-structural glycoprotein 1 NS1 J Virol Methods. Gelderblom HR. Structure and classification of viruses. In: Baron S, editor. Medical microbiology. Chapter Ghosh A, Dar L.

Dengue vaccines: challenges, development, current status and prospects. Indian J Med Microbiol. Cellular and humoral immunity to varicella zoster virus glycoproteins in immune and susceptible human subjects. Gubler DJ. Human arbovirus infections worldwide. Ann N Y Acad Sci. Dengue viral infections. Indian J Dermatol. Influenza, epidemiology and prevention of vaccine-preventable diseases. In: The Pink Book: course textbook.

Hansen JE. Carbohydrates of human immunodeficiency virus. Harvey David J. Mass Spectrom Rev. Probing virus-glycan interactions using glycan microarrays. Methods Mol Biol. Chikungunya: a bending reality. Microbes Infect. Evaluation of a dengue NS1 antigen detection assay sensitivity and specificity for the diagnosis of acute dengue virus infection.

Harris E, ed. Glycan receptor for influenza virus. Open Antimicrob Agents J. Hobson-Peters J. Approaches for the development of rapid serological assays for surveillance and diagnosis of infections caused by zoonotic flaviviruses of the japanese encephalitis virus serocomplex.

J Biomed Biotechnol. Fatal cases of Chikungunya virus infection in Colombia: diagnostic and treatment challenges. J Clin Virol. Development of global consensus of dengue virus envelope glycoprotein for epitopes based vaccine design. Curr Comput Aided Drug Des. Microbial evolution and co-adaptation: A tribute to the life and scientific legacies of joshua lederberg: workshop summary.

A clinico-hematological profile of dengue outbreak among healthcare Professionals in a tertiary care hospital of Ahmedabad with analysis on economic impact. Nat J Comm Med.

Structural basis of semaphorin-plexin signalling. Lu S, ed. Determination of specific antibody responses to the six species of ebola and marburg viruses by multiplexed protein microarrays.

Clin Vaccine Immunol. Synthetic GPI array to study antitoxic malaria response. Nat Chem Biol. Proteomic analysis of virus-host interactions in an infectious context using recombinant viruses. Mol Cell Proteomics. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site — in complex with antibody IGH J Mol Biol.

Identification of amino acids in the dengue virus type 2 envelope glycoprotein critical to virus infectivity. Semaphorins command cells to move. Nat Rev Mol Cell Biol. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Functional role of hepatitis C virus chimeric glycoproteins in the infectivity of pseudotyped virus. Brit Med J. In: Tan SL, editor. Hepatitis C viruses: genomes and molecular biology. Norfolk UK : Horizon Bioscience; Chapter 4.

High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections. Clin Infect Dis. Leroy EM. J Med Virol. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science New York, NY ; — Lo M, Ng EK. Molecular diagnosis of severe acute respiratory syndrome. A study of influenza and influenza-related complications among children in a large US health insurance plan database.

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. Nat Struct Biol. Mahony JB, Richardson S. Development of monoclonal antibodies to highly pathogenic avian influenza H5N1 virus and their application to diagnostics, prophylaxis, and therapy.

Acta Virol. Mathys L, Balzarini J. Several N-glycans on the HIV envelope glycoprotein gp preferentially locate near disulphide bridges and are required for efficient infectivity and virus transmission. Paxton WA, ed. Antibody response to human immunodeficiency virus in homosexual men: relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency and disease progression. J Clin Invest. Mirazimi A. Ebola virus disease: societal challenges and new treatments.